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3xSTaA14Q-LT(S63K/R192G/L211A) toxoid fusion for developing antitoxin vaccine against enterotoxigenic Escherichia coli associated diarrhea
Technology Benefits
A fusion carrying three copies of a STa toxoid to enhance anti-STa immunity, and a triple mutant L T to further eliminate LT enterotoxicity, for safe vaccine development.
Detailed Technology Description
The invention provides a fusion protein containing 3 copies of a STa mutant protein, as well as a triple mutant LT A1 fragment. This combination creates enhanced immunogenic response to STa as well as reducing the toxicity of the LT toxin. This can be applied to multiple vaccine delivery methods.
Country/Region
USA
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