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STa toxin and STa derivative used in toxoid development against enterotoxigenic Escherichia coli associated diarrhea
Technology Benefits
We have cloned the correct STa toxin gene into a high expression vector for plasmid p8835 to express STA toxin or STa toxoids.
Detailed Technology Description
SDSU has developed an expressing system for STa toxin and STa toxoid expression. Twenty-eight STa mutants were constructed and screened for structural integrity, and function. The STa toxoid genes were cloned into the pUC19 high copy plasmid as HindIII-BamHI fragments. The expressed mutant STa toxoid proteins induced a strong immune response relative to the control sample.
Country/Region
USA
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