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Rapid Development of Safer and More Robust Live Attenuated Bacterial Vaccines

Technology Benefits

Rapid development of live attenuated bacterial vaccinesMore robust and effective attenuation than current methodsAble to optimize the attenuation to achieve the desirable balance between protection and safety Applicable to a broad range of wild type gram negative pathogenic bacteria

Technology Application

Vaccine development for gram negative pathogenic bacteria.

Detailed Technology Description

Researchers at Montana State University have discovered a way to simply and easily generate attenuated live bacterial vaccines with controls that allow the attenuation to be optimized. The method consists of promoting the expression of genes that express bacterial cell surface appendages such as flagella that have the capability to attenuate the pathogenic cell. Another step provides for testing the efficacy of the attenuated cell and providing feedback to tightly adjust the attenuation at safely below the level of infection. The ability to easily attenuate and test the attenuation allows rapid generation of candidate vaccines without needing a deep understanding of the pathogenΓÇÖs mechanism of infection or virulence factors.

Country/Region

USA

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