A-42 ADAMTS-4: Therapeutics to functionally recover the injured spinal cord
- Technology Benefits
- ΓùÅ Safe because ADAMTS-4 is naturally found in the body (Using C-ABC to Human has been concerned in safety because it is derived from Gram negative bacterium, Proteus vulgaris.)ΓùÅ Easy to obtain recombinant ADAMTS-4ΓùÅ ADAMTS-4 affects in axon stretch growth even under the existence of both CSPG and KSPG.
- Technology Application
- ΓùÅ Works as a therapeutic against injured spinal cord, myelitis, brain injuries, and denatured neuron by brain ischemia and Intracranial hemorrhageΓùÅ May improve the retinopathy caused by neuropathyΓùÅ Could apply to injured brain.
- Detailed Technology Description
- With the addition of ADAMTS-4, Cerebellar granule neurons cultured with CSPG showed dramatic improvement in the axon stretch growth. The direct injection of ADAMTS-4 into ratsΓÇÖ injured spinal cords also led the significant improvements of their hindlimb movements. Its efficacy was almost as strong as that of Chondroitinase ABC (C-ABC), which inactivates CSPG by degrading its CS-chain.
- Supplementary Information
- Inventor: KADOMATSU Kenji | IMAGAMA Shiro | TAUCHI Ryoji
Priority Number: WO2012086474A1
IPC Current: A61K003800 | A61K004800 | A61P002500 | A61P002528
Assignee Applicant: National University Corporation Nagoya University
Title: THERAPEUTIC AGENT FOR CENTRAL NERVOUS SYSTEM DISEASES | AGENT THÉRAPEUTIQUE POUR DES MALADIES DU SYSTÈME NERVEUX CENTRAL
Usefulness: THERAPEUTIC AGENT FOR CENTRAL NERVOUS SYSTEM DISEASES | AGENT THÉRAPEUTIQUE POUR DES MALADIES DU SYSTÈME NERVEUX CENTRAL
Summary: The therapeutic agent is useful for treating central nervous diseases chosen from retinal disease, spinal injury, myelitis, brain damage, nerve cell degeneration, cerebral infarction, cerebral ischemia, intracerebral hemorrhage and damage of nerve cell, preferably spinal injury (all claimed).
Novelty: Therapeutic agent useful for treating central nervous diseases e.g. retinal disease, spinal injury, myelitis and brain damage, comprises ADAMTS-4 protein and expression vector containing ADAMTS-4 gene
- Industry
- Biomedical
- Sub Category
- DNA/Gene Engineering
- *Abstract
-
Researchers in Nagoya University uniquely focused on the enzyme, ADAMTS-4, which degrades the core protein of Proteoglycans.
- Country/Region
- USA
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