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Platelet endothelial cell adhesion molecule PECAM-1

Technology Benefits

Broad patent coverage includes testing methods, angiogenesisapplications, and inflammatory processes.

Technology Application

Covers PECAM-1 sequence, production of PECAM-1 isoforms andfragments, anti-sense constructs, therapeutic uses of PECAM, variantsand oligonucleotide probes to PECAM-1.

Detailed Technology Description

PECAM-1 plays a role in adhesion and signaling in platelets,leukocytes and endothelial cells, and regulates thrombosis, cellsurvival, and cellular responses to septic shock.The human platelet plasma membrane contains several hundred different proteins that control crucial functions, including adhesion to extracellular matrix, signal transduction, platelet aggregation, and clot retraction. Central to the ability of platelets to adhere to each other and to extracellular matrix is an abundant supply of cell surface adhesion molecules, including members of the integrin family, that exist in varying states of activation. These cell adhesion receptors, in turn, transmit signals into, and respond to signals from, the cell interior.Pharmaceutical applications especially in the field of inflammation.ΓÇ£PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.ΓÇØ Science. 1990 Mar 9;247(4947):1219-22.Composition of matter, Methods of usePatents 5,264,554; 5,668,012; 5,917,030; 6,020,188; 6,087,331

*Abstract

PECAM-1 plays a role in adhesion and signaling in platelets,leukocytes and endothelial cells, and regulates thrombosis, cellsurvival, and cellular responses to septic shock.

*Principal Investigator

Name: Peter Newman

Department:

Country/Region

USA