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R10Z8E9 a murine monoclonal antibody for quantification of therapeutic antibodies in non human primate trials

Technology Benefits: Detection and quantitation of humanized/human IgG antibody therapeutics in serum of non-human primates

Detailed Technology Description: ΓÇ£The antibody, R10Z8E9, designated pan anti-human IgG-Fc, does not react with serum from mouse, rat or the non-human primates marmoset, rhesus macaque, cynomolgus monkey and baboon in enzyme-linked immunosorbent assay (ELISA) or surface plasmon resonance technology (Biacore) format. In a capture assay R10Z8E9 allowed quantitation of a human IgG antibody therapeutic in spiked cynomolgus monkey serum via a Sandwich ELISA format. This generic human IgG assay has been applied in several pharmacokinetic studies in cynomolgus monkeys to determine serum levels of different therapeutic antibodies.*ΓÇØ*Stubenrauch K, et al. J Pharma Biomed Analysis 9:1003-1008 (2009)

*Abstract: Detection and quantitation of humanized/human IgG antibody therapeutics in serum of non-human primates

*Principal Investigator: Name: Prof. Roy Jefferis
Department:

Country/Region: USA

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