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Novel Imaging and Therapeutic Nanoparitcles

Technology Benefits

Main Advantages of this InventionΓÇóCan be used to treat a wide variety of diseases (Cancer, AIDS, Infectious diseases)ΓÇóFlexible constructΓÇóImproved nanoparticle design and versatility over current ones.

Technology Application

Potential Areas of Application ΓÇó Drug deliveryΓÇó Medical imagingΓÇó Personalized medicine

Detailed Technology Description

None

Supplementary Information

Patent Number: US8916135B2
Application Number: US2008197061A
Inventor: Boyes, Stephen G. | Rowe, Misty D. | Thamm, Douglas H. | Kraft, Susan L.
Priority Date: 22 Aug 2007
Priority Number: US8916135B2
Application Date: 22 Aug 2008
Publication Date: 23 Dec 2014
IPC Current: A61K004906 | A61K004918 | B82Y000500 | C07F000500 | A61B0005055
US Class: 424009322
Assignee Applicant: Colorado School of Mines,Golden | Colorado State University Research Foundation,Fort Collins
Title: Lanthanide nanoparticle conjugates and uses thereof
Usefulness: Lanthanide nanoparticle conjugates and uses thereof
Summary: In pharmaceutical compositions and for targeting, treating and/or imaging a disease or disorder in a patient (claimed). The disease or disorder includes cancer. Also useful for a wide variety of different drug delivery applications, such as gene therapy, imaging applications, such as vascular imaging, and even in external molecular detection devices, such as microarrays and assays.
Novelty: New gadolinium nanoparticle conjugate for targeting, imaging or treating e.g. cancer, comprises a gadolinium nanoparticle grafted onto a polymer or polymer precursor having a functional group as point of attachment to the nanoparticle

Industry

Disease Diagnostic/Treatment

Sub Category

Cancer/Tumor

*Abstract

This invention involves the modification of the surface of gold and gadolinium particles for targeted imaging and therapies. The invention has four parts:ΓÇóMethod(s) for the preparation of hybrid nanoparticles consisting of gold nanorods or gadolinium nanoparticles coated with a metal organic framework structure for the purpose of multimodal diagnostic imagingΓÇóModified nanoparticles for targeted imaging and treatment of disease ΓÇóUse of the hybrid nanoparticles and chemical modification of the nanoparticles to image and treat diseaseΓÇóComposition of the chemical constitution of the hybrid nanoparticles.

*Principal Investigator

Name: Misty Rowe

Department:

Name: Stephen Boyes

Department:

Country/Region

USA