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Microfluidic Flow Assay for Measuring Hemostatic Phenotypes

Technology Benefits

Main Advantages of this InventionΓÇóMeasures clotting ability in non-static stateΓÇóTest for both platelet function and coagulation

Technology Application

Potential Areas of Application ΓÇóMedical testingΓÇóLaboratory use

Detailed Technology Description

None

Supplementary Information

Patent Number: US8486349B2
Application Number: US13045404A
Inventor: Neeves, Keith Benjamin | Hansen, Ryan R.
Priority Date: 12 Mar 2010
Priority Number: US8486349B2
Application Date: 10 Mar 2011
Publication Date: 16 Jul 2013
IPC Current: B01L000300
US Class: 422502 | 422052 | 422063 | 422064 | 42208205 | 42208208 | 42208209 | 42208211 | 422407 | 422425 | 422426 | 422429 | 422500 | 422501 | 422503 | 422504 | 435004 | 435005 | 43500611 | 43500612 | 43500619 | 4350071 | 4350072 | 4350079 | 435029 | 435164 | 435165 | 4352831 | 4352864 | 4352871 | 4352872 | 4352885 | 4352887 | 436043 | 436052 | 436053 | 436149 | 436164 | 436165 | 436166 | 436172 | 436174 | 436180 | 436518 | 436524 | 436805
Assignee Applicant: Colorado School of Mines,Golden
Title: Microfluidic flow assay for measuring hemostatic phenotypes
Usefulness: Microfluidic flow assay for measuring hemostatic phenotypes
Summary: The microfluidic device is useful for measuring clotting characteristics of blood (claimed), analyzing bleeding and thrombotic disorders, dosing anticoagulant and antiplatelet drugs, and tracking the effects of pharmacological interventions on thrombosis.
Novelty: Microfluidic device, used for e.g. measuring clotting characteristics of blood and analyzing bleeding and thrombotic disorders, comprises microfluidic channel and prothrombotic surface provided in the microfluidic channel

Industry

Chemical/Material

Sub Category

Chemical/Material Application

Application No.

US13045404A

*Abstract

In this invention we report a method for measuring an individualΓÇÖs ability to form a blood clot. The assay consists of a micropatterned surface that induces clot formation and an array of microfluidic channels through which blood flows. The micropatterned surface contains two stimuli, one for inducing platelet adhesion and another for inducing the coagulation cascade. Most current bleeding assays test for either platelet function or coagulation, but not both. In addition, most of these conventional assays occur under static, or no flow, conditions. However, since blood is a moving fluid in the body, there are several advantages to studying it under flow in bleeding diagnostics.

*Principal Investigator

Name: Keith Neeves

Department:

Name: Ryan Hansen

Department:

Country/Region

USA