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Normalization of Time Domain-Optical Coherence Tomography (TD-OCT) Retinal Nerve Fiber Layer Thickness Measurements

Detailed Technology Description

None

*Abstract

BackgroundOptical coherence tomography is a low-coherence, interferometer-based, noninvasive medical imaging modality that can provide non-contact, real-time, high-resolution, cross-sectional images of biological tissue. TD-OCT (time domain OCT) has been widely accepted to quantitatively assess the Retinal Nerve Fiber Layer (RNFL) which is advantageous in the diagnosis and monitoring of the progression of glaucoma, the second leading cause of blindness worldwide. Previous studies have shown that structual changes of both RNFL thickness and ONH shape can be early indicators for glaucomatous abnormality. Many times glaucomatous progression by Visual Field (VF) is detected only after significant RNFL loss has already occurred. RNFL measurements using repeated OCT scans at different time points (months or years) are needed to detect glaucoma progression, which can appear earier than VF changes. TechnologyThe goal of the subject invention is to normalize the Retinal Nerve Fiber Layer (RNFL) thickness measurements of off-centered TD-OCT circle scans to a universal (virtual) location centered on the Optic Nerve Head (ONH) of the same eye. Both a mathematical model of the retinal tissue pattern and a scan location matching (SLM) algorithm. (ID01633, PCT/US2009/052951) are used for this calculation. Using the normalized RNFL thickness measurements avoids the previous downfall of RNFL thickness measurement variability. This makes it possible for clinicians to track, compare, and detect any retinal changes over a longer period of time (independent of imaging modality i.e. TD-OCTor SD-OCT).There is currently no technology / methodology to provide backward compatibility between two-dimensional (2D) TD-OCT scans and three-dimensional (3D) SD-OCT volumetric data.Application1. Allows clinicians to track, compare and detect retinal changes over a longer period of time.Advantages1. RNFL thickness measurement normalization of off-centered TD-OCT circle scans to a universal (virtual) location centered on the ONH.2. Mathematical model of the retinal tissue pattern by using 3D SD-OCT volume.3. Improved Reproducibility of TD-OCT scan.Stage of DevelopmentAlgorithm successfully tested on 12 healthy eyes from 12 healthy subjects from UPMC Eye Center.Provisional Patent Application filed

*Principal Investigator

Name: Hiroshi Ishikawa, Associate Professor, Director

Department: Med-Ophthalmology

Name: Jongsick Kim

Department: Med-Medicine

Name: Joel Schuman, Professor & Chairman of Ophthalmology

Department: Med-Ophthalmology

Name: Chaim-Gadi Wollstein

Department: Med-Ophthalmology

Country/Region

USA