anti-HLA-DR, -DQ and -DP beta chains mAb LGII-612.14 and hybridoma cell line
- Detailed Technology Description
- None
- *Abstract
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Major histocompatibility complex (MHC) is a cell surface molecule that mediates interactions with immune cells thru the presentation of peptides. MHC is dived into three groups; class I, class II, and class III. MHC class II is formed of two chains, ╬▒ and ╬▓, each having two domains ╬▒1 and ╬▒2 and ╬▓1 and ╬▓2. ╬▒2 and ╬▓2 function as the transmembrane domain, anchoring the MHC molecule to the cell membrane. The peptide binding groove is formed of the heterodimer of ╬▒1 and ╬▓1.The human leukocyte antigen (HLA) is the corresponding name of the major histocompatibility complex (MHC) in humans. HLA molecules are divided into two subgroups; class I and II. HLA class II molecules (DP, DM, DOA, DOB, DQ, and DR) present extracellular antigens to T-lymphocytes.Monoclonal antibody LGII-612.14 recognizes the beta chains of the HLA -DR, -DQ and -DP. Validated Uses:Western BlotImmunopercipitationImmunohistochemistry-Formalin Fixed TissueReferences:J. Immunol. Methods 161:239-256, 1993Available for non commercial license as a research tool
- *Principal Investigator
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Name: Soldano Ferrone, Professor
Department: Department of Surgery
- Country/Region
- USA
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