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Impeller Designs for an Internal Impeller Respiratory Assist Catheter (iPRAC)

Detailed Technology Description

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*Abstract

Acute respiratory failure remains a significant healthcare problem. Affected patients are most often supported using mechanical ventilation. Ventilatory support can further damage the lungs and is far from an ideal therapy despite recent improvements. This invention involves a small catheter that can be percutaneously inserted into the venous system and used by intensivists to help assist breathing in patients with acute and acute-on-chronic lung failure. Many of these patients can be managed for oxygenation, but CO2 retention is problematic. This device is designed primarily for CO2 removal but it also supplies oxygen. The device uses a slender bundle of hollow fiber membranes (blood oxygenator fibers) for gas exchange with blood. The inventors have developed a strategy for increasing CO2 removal by using rotational mixing impellers within the hollow fiber bundle. Applications1) acute lung failure (ARDS) 2) acute-on-chronic lung failure (ae-COPD)Advantages1) Reduces need for intubationStage of DevelopmentThe device has been successfully implanted in the acute calf model and the inventors have studied its in-situ gas exchange and effect on blood and hemodynamics.

*Principal Investigator

Name: William Federspiel, Associate Professor

Department: Bioengineering

Name: Brian Frankowski, Designer/Fabricator

Department: Med-McGowan Inst Regenerative Med

Name: Samuel Lieber

Department: Med-McGowan Inst Regenerative Med

Name: Kevin Mihelc

Department: Bioengineering

Country/Region

USA