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Modeling Wound Healing

Detailed Technology Description

None

*Abstract

Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis.

*Principal Investigator

Name: Gilles Clermont

Department: Med-Critical Care Medicine

Name: Patricia Hebda, Research Associate Professor

Department: Med-Plastic Surgery

Name: Yee Li, (Nicole)

Department: SHRS-Commu Science & Disorders

Name: Qi Mi

Department: SHRS-Sports Medicine and Nutrition

Name: David Steed, Professor

Department: Med-Surgery

Name: Katherine Verdolini-Abbott, Faculty

Department: SHRS-Commu Science & Disorders

Name: Yoram Vodovotz, Associate Professor of Surgery

Department: Med-Surgery

Country/Region

USA