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KSHV LANA1 sequence that inhibits protein turnover and CTL antigen processing

Detailed Technology Description: None

*Abstract: Vaccines can be made against KSHV by generating a protein with the central repeat domain deleted. These antigens will have enhanced immunogenicity against the remaining N-terminal and C-terminal peptides. Alternatively, the central repeat domain can be cloned as a fusion protein into a gene delivery vector. Expression of the central repeat domain will increase protein stabilization and decrease immunogenicity of the transgenic protein. The LANA1 repeat domain may be a useful and simple means to increase gene therapy delivered protein expression.Possible applications of this invention include:-KSHV vaccine-Gene therapyProvisional Patent Application Filed

*Principal Investigator: Name: Yuan Chang, Professor, Pathology
Department: Med-Pathology

Name: Patrick Moore, Director
Department: Med-Microbiology and Molecular Genetics

Country/Region: USA

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