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In vitro human muscarinic receptor binding assay

Detailed Technology Description: None

*Abstract: Many medications including certain antidepressants, antihistamines, antispasmodics, neuroleptics and antiarrythmics may cause anticholinergic side effects. These effects range from peripheral autonomic effects (dry mouth, constipation) to more serious central effects including cognitive impairment and delirium. Anticholinergic effects are cumulative and the elderly who take on average of three prescription medications are especially at risk for developing serious anticholinergic side effects. Our laboratory has developed an in vitro assay that measures the total serum anticholinergicity. This assay would be useful for drug discovery. It could determine if new therapeutic agents have anticholinergic properties.Available for non-exclusive license.

*Principal Investigator: Name: B. Richard Cumbie, Research Associate Sr
Department: Med-Psychiatry

Name: Margaret Kirshner, Laboratory Manager
Department: Med-Psychiatry

Name: Bruce Pollock
Department: Med-Psychiatry

Country/Region: USA

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