Estradiol Metabolites for the Treatment of Pulmonary Hypertension
- Detailed Technology Description
- None
- *Abstract
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The present invention relates to methods of treating pulmonary hypertension and its sequelae including heart failure and pulmonary and cardiac dysfunction using estradiol metabolites. More particularly, the present invention relates to the use of estradiol metabolites with little estrogenic activity such as 2-hydroxyestradiol, 4-hydroxyestradiol, 2-methoxyestrodiol, and 4-methoxyestradiol, all of which may be delivered in a controlled release formulation for the treatment of pulmonary hypertension and associated conditions. The present invention is particularly useful because the estradiol metabolites used therein have few side effects. In addition, estradiol metabolites can be administered in pharmaceutical formulations that provides for sustained release, an improvement that will provide for the widespread use of the compositions as therapeutics for the treatment of pulmonary hypertension and associated conditions.
- *Principal Investigator
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Name: Edwin Jackson, Professor of Pharmacology and Medicine
Department: Med-Pharmacology and Chemical Biology
Name: Stevan Tofovic, Assistant Professor
Department: Med-Medicine
- Country/Region
- USA
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