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Anti-mouse P84 (a.k.a. CD172a, SIRPa, BIT, SHPS-1) monoclonal antibody (mAb) and rat hybridoma cell line

Detailed Technology Description
None
*Abstract
The inventors have developed an IgG1 rat mAb against the mouse P84 (a.k.a. CD172a, SIRPa, BIT, SHPS-1) protein1. P84 is expressed in subset of neurons throughout the CNS2, retina3, macrophages, and bone marrow myeloid cells. P84 predominate ligand is CD47 or Integrin-Associated Protein (IAP). P84 and IAP represent a heterophilic binding pair that is likely to be involved in bi-directional signaling at the synapse and other tissues4.Validated Uses:* Western blot* Immunohistochemistry* Flow CytometryReferences1. Dev Biol. 1990 Feb;137(2):219-32.2. J Neurosci. 1997 Nov 15;17(22):8702-10.3. J Comp Neurol. 2000 Jan 17;416(3):335-44.4. J Biol Chem. 1999 Jan 8;274(2):559-62.Non exclusive license available
*Principal Investigator

Name: Carl Lagenaur

Department: Med-Neurobiology
Country/Region
USA

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