Rapid Isolation of T Cell Epitopes from Viable Cells by Mild Acid Elution
- Detailed Technology Description
- None
- *Abstract
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Methods are provided for eluting peptides that are bound to major histocompatibility complex ("MHC") molecules expressed on the cell surfaces of viable cells that have at least one MHC-peptide complex on the surfaces of the cells. Methods are provided for using such acid-eluted T cell epitopes, preferably obtained from a patient's tumor, and autologous dendritic cells as the basis for antitumor vaccines
- *Principal Investigator
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Name: Michael Lotze, VP and Director High Throughput Biology
Department: Med-Surgery
Name: Walter Storkus, Professor
Department: Med-Dermatology
- Country/Region
- USA
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