A-38 Oxidative Stress Evaluating Device
ΓùÅ Novel: It is the worldΓÇÖs first device to detect and measure oxidative stress from erythrocytesΓùÅ Fast and Easy: Evaluation procedure is very simpleΓùÅ Portable: The device is small enough to be portable
ΓùÅ Oxidative stress evaluating device for diabetes patientsΓùÅ Risk testing device for diseases including, angiopahy, arterial sclerosis, metabolic syndromes, cancer, Alzheimer's diseaseΓùÅ Screening device for potential oxidative stress drugs
Oxidative stress represents an imbalance between the production and manifestation of reactive oxygen species (ROS) and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. In humans, oxidative stress is involved in many diseases. Increasing evidence in studies suggests that oxidative stress plays a major role in the pathogenesis of both types of diabetes. Free radicals are formed disproportionately in diabetes by glucose oxidation, nonenzymatic glycation of proteins, and the subsequent oxidative degradation of glycated proteins. Abnormally high levels of free radicals and the simultaneous decline of antioxidant defense mechanisms can lead to damage of cellular organelles and enzymes, increased lipid peroxidation, and development of insulin resistance. It is also known that the amount of glycosylation on the surface of an erythrocyte changes by exposure to oxidative stress and the electric charge of an erythrocyte depends on the amount of glycosylation on the surface of the erythrocyte. Researchers have invented a device to evaluate oxidative stress by measuring the amount of glycosylated erythrocytes using an electrochemical measuring method. This device can be used to measure the level of oxidative stress in diabetes patients and is useful to predict the risk of diseases induced by oxidative stress.
Inventor: HONDA Hiroyuki | OKOCHI Mina | ISAJI Yayoi | HAMADA Yoji | NAGASAKI Hiroshi
Priority Number: WO2010147206A1
IPC Current: G01N0027416 | G01N002748 | G01N003315 | G01N003348 | G01N003349 | G01N003350
Assignee Applicant: National University Corporation Nagoya University
Title: METHOD FOR EVALUATING OXIDATION STRESS AND USE OF THE SAME | METHODE D'EVALUATION DU STRESS OXIDATIF ET UTILISATION ASSOCIEE
Usefulness: METHOD FOR EVALUATING OXIDATION STRESS AND USE OF THE SAME | METHODE D'EVALUATION DU STRESS OXIDATIF ET UTILISATION ASSOCIEE
Summary: Oxidative stress evaluation method for examination of diseases such as angiopathy, arteriosclerosis, or diabetic complication (all claimed). Can also be used in examination of other disease such as cancer, metabolic syndrome and Alzheimer disease.
Novelty: Oxidative stress evaluation method for examination of disease, involves detecting degree of adhesion of erythrocytes with respect to working electrode based on measurement result
Disease Diagnostic/Treatment
Cancer/Tumor
USA
