Method of producing recombinant biological products
Issued patent
A method of producing a recombinant biological product, which method employs a mammalian producer cell culture, comprises the steps of generating a biomass of mammalian producer during an initial phase of cell culture, and causing an increase in a level of one or more of the miRNA molecules within the mammalian producer cells once a desired concentration of mammalian producer cells has been achieved.
Sale, License agreement
Patent Number: US8476244B2
Application Number: US2009376345A
Inventor: Gammell, Patrick | Barron, Niall | Clynes, Martin
Priority Date: 4 Aug 2006
Priority Number: US8476244B2
Application Date: 20 Mar 2009
Publication Date: 2 Jul 2013
IPC Current: C12N001511
US Class: 514044A
Assignee Applicant: Dublin City University,Dublin
Title: Method of producing recombinant biological products
Usefulness: Method of producing recombinant biological products
Summary: The method is useful for producing a recombinant biological product which employs a mammalian producer cell culture (claimed).
Biomedical
DNA/Gene Engineering
US
The main commercial application of this work is to generate cell lines stably expressing these miRNAs in either constitutive or inducible formats to be used as future cell factories for the production of biopharmaceuticals. Naturally there are licencing opportunities for the use of this technology to engineer existing proprietary CHO variants e.g. within the biopharmaceutical industry.
Ireland
