DIARYLAMINE-BASED FLUOROGENIC PROBES FOR DETECTION OF PEROXYNITRITE
Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening peroxynitrite. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining peroxynitrite in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of peroxynitrite in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite in chemical and biological samples.
Patent Number: US20130196362A1
Application Number: US13754499A
Inventor: Yang, Dan | Peng, Pao
Priority Date: 30 Jan 2012
Priority Number: US20130196362A1
Application Date: 30 Jan 2013
Publication Date: 1 Aug 2013
IPC Current: G01N003122 | G01N003358
US Class: 435029 | 436107 | 544229 | 544230 | 544337 | 546014 | 546015 | 546062 | 549225 | 549265 | 549394 | 556406
Assignee Applicant: The University of Hong Kong
Title: DIARYLAMINE-BASED FLUOROGENIC PROBES FOR DETECTION OF PEROXYNITRITE
Usefulness: DIARYLAMINE-BASED FLUOROGENIC PROBES FOR DETECTION OF PEROXYNITRITE
Summary: (Q) are useful for detecting, measuring and/or screening the level of peroxynitrite in a sample, which is a chemical sample or biological sample comprising a microorganism, or a cell or tissue (all claimed).
Novelty: New substituted 9H-xanthene compounds, useful for detecting, measuring and/or screening the level of peroxynitrite in a sample including a chemical/biological sample including a microorganism, or a cell or tissue
Biomedical
Medical Imaging
USA
