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NUCLEIC ACID APTAMERS AGAINST PLASMODIUM LACTATE DEHYDROGENASE AND HISTIDINE-RICH PROTEIN II AND USES THEREOF FOR MALARIA DIAGNOSIS

Summary

The present invention provides nucleic acid aptamers that bind to Plasmodium proteins lactate dehydrogenase and histidine-rich protein II, and uses thereof for the diagnosis of malaria. Aptamers against histidine-rich protein II may be used to detect the presence of Plasmodium species in general, whereas aptamers against lactate dehydrogenase can be used to specifically detect Plasmodium falciparum.

Supplementary Information

Inventor: TANNER, Julian Alexander | CHEUNG, Yee Wai | KOTAKA, Masayo
Priority Number: WO2013117162A1
IPC Current: C12Q000168 | C07H002104
Assignee Applicant: The University of Hong Kong
Title: NUCLEIC ACID APTAMERS AGAINST PLASMODIUM LACTATE DEHYDROGENASE AND HISTIDINE-RICH PROTEIN II AND USES THEREOF FOR MALARIA DIAGNOSIS | APTAMÈRES D'ACIDE NUCLÉIQUE CONTRE LA LACTICODÉSHYDROGÉNASE DE PLASMODIUM ET LA PROTÉINE II RICHE EN HISTIDINE, ET LEURS
Usefulness: NUCLEIC ACID APTAMERS AGAINST PLASMODIUM LACTATE DEHYDROGENASE AND HISTIDINE-RICH PROTEIN II AND USES THEREOF FOR MALARIA DIAGNOSIS | APTAMÈRES D'ACIDE NUCLÉIQUE CONTRE LA LACTICODÉSHYDROGÉNASE DE PLASMODIUM ET LA PROTÉINE II RICHE EN HISTIDINE, ET LEURS UTILISATIONS POUR LE DIAGNOSTIC DU PALUDISME
Summary: For detecting the presence of Plasmodium in a sample; or determining the formation of the binding complex between the nucleic acid aptamer and Plasmodium lactate dehydrogenase (LDH) or Plasmodium histidine-rich protein II (HRPII) (all claimed); for the diagnosis and treatment of malaria; for detecting Plasmodium falciparum , Plasmodium yoelii , Plasmodium knowlesi , Plasmodium brasilaneum , Plasmodium ovale , Plasmodium chabaudi , Plasmodium vivax , Plasmodium malaria , Plasmodium berghei , Plasmodium reichenowi , and Plasmodium gallinaceum .
Novelty: New aptamer binding to Plasmodium lactate dehydrogenase or Plasmodium histidine rich protein II, comprising a nucleic acid sequence having specific identity to specific nucleic acid sequences for detecting presence of Plasmodium in a sample

Industry

Biomedical

Sub Group

Pathogen

Application No.

13/763,051

Country/Region

USA

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