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Modified b-lactamases and Uses Thereof

Summary: A tool that can screen bacteria for .beta.-lactamases against a panel of various antibiotics is desirable. A biosensor incorporating an indicator molecule into .beta.-lactamases may achieve this purpose, but it requires that the attached indicator molecule must not impair the binding affinity of the protein to a great extent to provide a higher sensitivity. A modified .beta.-lactamases with a residue on the .OMEGA.-loop or outside the .OMEGA.-loop but close to the active site of .beta.-lactamase being replaced by a reactive residue is developed in this invention.

Supplementary Information: Patent Number: CN102887479B
Application Number: CN201210254407A
Inventor: HUANG, Guan-feng | LI, Ming-hong | YE, She-ping
Priority Date: 20 Jul 2011
Priority Number: CN102887479B
Application Date: 20 Jul 2012
Publication Date: 16 Apr 2014
IPC Current: C12Q000168
Assignee Applicant: The Hong Kong University of Science & Technology
Title: High polymer-nanoparticle conjugates and method for their stabilization, analysis system and therapeutic agent carrier | Ultra-stable oligonucleotide-gold and-silver nanoparticle conjugates and method of their preparation
Usefulness: High polymer-nanoparticle conjugates and method for their stabilization, analysis system and therapeutic agent carrier | Ultra-stable oligonucleotide-gold and-silver nanoparticle conjugates and method of their preparation
Summary: The method is useful for stabilizing conjugates between macromolecule and nanoparticle, where the stabilized conjugates are useful in vitro diagnostics e.g. clinical diagnostics, environmental surveillance, food monitoring, forensic analysis and biowarfare agent detection, in vivo imaging, therapeutics e.g. gene and chemodrug delivery and construction of DNA-templated nanostructure.
Novelty: Stabilizing conjugates between macromolecule e.g. biomolecule and nanoparticle involves chemisorbing or adsorbing several macromolecules onto surface of nanoparticle and coating reinforcement layer on surface of particle

Industry: Biomedical

Sub Category: Medical Imaging

Application Date: 41110

Application No.: 201210254407.8

Others: WONG Kwok-yin
LEUNG Yun-chung Thomas
CHAN Pak-ho

Country/Region: USA

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