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Method of Using Rhein for Treating or Preventing Sonic Hedgehog Signaling-Related Disease or Disorder

Summary
The present invention relates to a method of using rhein in treatment and/or prophylaxis of sonic hedgehog signaling-dependent disease or disorder.
Technology Benefits
Providing a pharmaceutical composition comprising a therapeutically effective amount of rhein for treatment and/or prophylaxis of disease or disorder depending on sonic hedgehog signaling pathway.
Technology Application
For the treatment and/or prophylaxis of the disease or disorder
Detailed Technology Description
The present invention relates to the method of using a therapeutically effective amount of anthraquinone derivative, namely 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, also known as rhein, as an inhibitor of sonic hedgehog signaling pathway for the treatment and/or prophylaxis of the disease or disorder depending on the signaling pathway such as fibrotic conditions, stellate cell-related pathologies, inflammatory activities and/or proliferative diseases including tumors and adenocarcinoma.
Supplementary Information
Inventor: XU R | LI X | FUNG P C W
Priority Number: CN1829797A
IPC Current: C12N001551 | A61K003576 | A61K003844 | A61K004800 | C12N001566 | C12N001586 | C12N0015864
Assignee Applicant: The University of Hong Kong
Title: Compositions and methods for preventing and treating liver cirrhosis | Composition and method for preventing and treating hepatocirrhosis
Usefulness: Compositions and methods for preventing and treating liver cirrhosis | Composition and method for preventing and treating hepatocirrhosis
Summary: (M1) is useful for treating liver cirrhosis in a subject, which is a mammal such as a human. (M2) is useful for preventing or retarding the development of liver cirrhosis in a subject (claimed).
Industry
Disease Diagnostic/Treatment
Sub Category
Other Disease
Application Date
2013.08.09
Application No.
US 13/962,977
Others
Filed
ID No.
A61/BZ/Rshh/US01
Country/Region
Hong Kong

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