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Saponins derived from Ilex pubescens and method of purifying the same

Summary

It introduces a novel triterpene saponin fraction (named PSF) with anti-inflammatory and analgesic activities. Two hitherto unreported novel triterpene saponins were isolated in substantially pure form from the root of Ilex pubescens. The chemical structures and some properties of the triterpene saponin fraction have been elucidated to possess anti-inflammatory and analgesic activity. These two novel triterpene saponins and the triterpene saponin fraction may be used as pharmaceutical compositions in humans and mammals in need of such treatment.

Technology Benefits

Suitable for oral administration with better efficacy, Pure herbal extracts with minimal side effect

Technology Application

Treat inflammation and pain in a mammalation and pain

Detailed Technology Description

It introduces a novel triterpene saponin fraction (named PSF) with anti-inflammatory and analgesic activities, and a pharmaceutical composition containing this fraction, and provides a method of preparing PSF from a plant material by extraction and purification. The plant material can be, for example, the dried root of Ilex pubescens.

Supplementary Information

Patent Number: US7544668B2
Application Number: US2006560849A
Inventor: Liu, Liang | Wang, Jing Rong | Zhou, Hua | Jiang, Zhi Hong
Priority Date: 17 Nov 2006
Priority Number: US7544668B2
Application Date: 17 Nov 2006
Publication Date: 9 Jun 2009
IPC Current: A61K00317004
US Class: 514033 | 424728 | 424736 | 514025 | 514027 | 514462
Assignee Applicant: Hong Kong Baptist University
Title: Saponins derived from Ilex pubescens and method of purifying the same
Usefulness: Saponins derived from Ilex pubescens and method of purifying the same
Summary: (II) is useful to treat inflammation and pain in a mammal. The anti-inflammatory effect of (II) (pubescenoside C and D) was tested in carrageenan induced paw edema in rats. The results showed that (II) reduced the swelling to 52.02± 13.83(%) in 4 hours.
Novelty: Composition, useful to treat inflammation and pain in mammal, comprises mixture of triterpene saponins comprising e.g. ilexsaponin, pubescenoside, ilexsaponin and chikusctsusaponin

Industry

Biomedical

Sub Category

Medical Composition

Application Date

2006.11.07

Application No.

US 11/560,849

Others

Granted

ID No.

A61/LL/Sapo/US01

Country/Region

Hong Kong