Compositions And Methods For Controlling Proliferation And Differentiation Of Cells
Methods And Compositions For Modulating Cell Differentiation, Proliferation And Morphology In Vitro Or In Vivo Are Described. The Methods Include Modifying The Extracellular Nanoenvironment Of Stem Cells With A Self-Assembling Peptide Nanofiber Scaffold. The Extracellular Nanoenvironment Can Be Modified By Changing The Percentage Of Self-Assembling Peptides Used To Form The Nanofiber Scaffold, The Concentration Of Cells In The Nanofiber Scaffold, The Ph, Or The Amounts Of Serum. Modulating The Extracellular Nanoenvironment Of Cells In Nanofiber Scaffold Allows For Increased Targeting Of Cell Placement And Therapeutic Delivery, Amplified By Cell Encapsulation And Implantation.
Patent Number: US9084752B2
Application Number: US2010966612A
Inventor: Ellis-Behnke, Rutledge | Tay, David Kiong-Chiu
Priority Date: 14 Dec 2009
Priority Number: US9084752B2
Application Date: 13 Dec 2010
Publication Date: 21 Jul 2015
IPC Current: A61K003810 | A61K003512 | C12N000500
US Class: 1001
Assignee Applicant: The University of Hong Kong
Title: Compositions and methods for controlling proliferation and differentiation of cells
Usefulness: Compositions and methods for controlling proliferation and differentiation of cells
Summary: In the preparation of agent for repairing tissue in a subject (claimed). For generating or preparing tissue or organs for transplantation in vivo; in the treatment of injured, diseased, or defective tissue including brain, spinal chord, muscle, heart, lung, kidney, liver, pancreas, skin, cornea, hematopoietic stem cells, bone, cartilage, uterus, bowel, islets of langerhans, ovary, fascia, pericardium, sclera, and vascular tissue, whole or in part (e.g. individual cell types associated with each organ); and for facilitating wound repair, acute or chronic wound care.
Novelty: Composition useful for repairing tissue in subject, comprises multi-, toti- or pluripotent cells and peptides forming self-assembling peptide nanofiber scaffold reduces or stops proliferation or differentiation of the cells
Disease Diagnostic/Treatment
Cancer/Tumor
Hong Kong
