Bioengineered Intervertebral Discs And Methods For Their Preparation
- Summary
- A Bioengineered Ivd For Disc Replacement Has Been Developed That Has Mechanical And Structural Support Characteristics Similar To Those Of Native Ivd. Extracellular Matrix (Ecm) Provides Support To Living Cell Components And Interacts With The Living Cellular Components During The Fabrication Process Without Introducing Toxicity. The Composition Can Be Produced From Both Natural Or Synthetic Source But Preferably Natural And Induced To Self-Assemble Or Reconstitute Into Its Solid Form Under Conditions That Are Mild Enough To Support Cellular Survival And Growth. The Cells Induce A Volume Change Of The Structures, Leading To Changes In Dimension, Ecm Density, Cell Density Mechanical Property And Stability, Etc. The Extent Of The Change I Volume Of The Composition Can Be Precisely Controlled By Factors Such As The Density Of The Ecm, The Density Of The Living Cells, The Timing For Interaction And The Serum Concentration. Increased Structural Support Is Provided By Crosslinking.
- Supplementary Information
- Patent Number: US8734827B2
Application Number: US2007742040A
Inventor: Chan, Barbara Pui | Cheung, Kenneth Man-Chee | Chan, Danny | Chan, Godfrey Chi-Fung | Hui, Ting Yan
Priority Date: 28 Apr 2006
Priority Number: US8734827B2
Application Date: 30 Apr 2007
Publication Date: 27 May 2014
IPC Current: A61F000244 | A61F000228 | A61K003839 | C12N00050775
US Class: 424423 | 4240937 | 424422 | 435366 | 435401
Assignee Applicant: The University of Hong Kong
Title: Bioengineered intervertebral discs and methods for their preparation
Usefulness: Bioengineered intervertebral discs and methods for their preparation
Summary: The composition of bioengineered IVD is useful for disc replacement. For expanding bone marrow derived MSCs (both claimed).
- Industry
- Biomedical
- Sub Category
- Medical Implant
- Application No.
- US2007742040A
- Country/Region
- Hong Kong
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