Cadherin-17 As Diagnostic Marker And Therapeutic Target For Liver Cancer
- Summary
- Compositions And Methods For Diagnosing, Treating And/Or Preventing Cancers Characterized By Cdh17 Overexpression Based On The Detection Of Cdh17 Or The Use Of Cdh17 As A Target For Therapeutic Intervention Or Prophylactic Intervention Are Provided. Methods For Diagnosing And/Or Monitoring Liver Cancers Using The Expressing Of Cdh17 Involve Detecting And/Or Quantitating The Cdh17 Protein Or Encoding Nucleic Acids (Dna Or Rna) In A Biological Sample Such As Urine From The Subject. Methods For Treating Liver Cancers Using Cdh17 As A Target And Of Sensitizing Cells With Aberrant Expression Of Cdh17 Have Also Been Developed. The Methods Include Suppression Or Knockdown Of The Expression Of Cdh17 By Administering An Effective Amount Of A Cdh17 Inhibitor.
- Supplementary Information
- Patent Number: US9207242B2
Application Number: US2009569386A
Inventor: Luk, John Moon Ching | Lee, Nikki Pui Yue | Liu, Lingxiao | Poon, Ronnie Tung Ping | Fan, Sheung Tat
Priority Date: 9 Oct 2008
Priority Number: US9207242B2
Application Date: 29 Sep 2009
Publication Date: 8 Dec 2015
IPC Current: C07K001628 | C07K001630 | G01N0033574
Assignee Applicant: The University of Hong Kong
Title: Cadherin-17 as diagnostic marker and therapeutic target for liver cancer
Usefulness: Cadherin-17 as diagnostic marker and therapeutic target for liver cancer
Summary: The methods and compositions are useful for diagnosing a cancer having the overexpression and/or upregulation of CDH17, and for killing cancer cells or rendering cells of a cancer involving the overexpression and/or upregulation of CDH17 more susceptible to a chemotherapeutic substance. The cancer is hepatocellular carcinoma (all claimed).
- Industry
- Disease Diagnostic/Treatment
- Sub Category
- Cancer/Tumor
- Application No.
- US2009569386A
- Country/Region
- Hong Kong
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