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COMPOSITIONS AND METHODS FOR TREATING CHRONIC RESPIRATORY INFLAMMATION

Summary

Neutrophil elastase (NE) is a protease secreted by neutrophils during inflammation. Aberrant expression of NE such as in chronic respiratory inflammatory diseases, results in tissue destruction and decline in lung function. Compositions including an NE-targeting agent that targets the pathologic elements of respiratory inflammation are provided. Non-anticoagulant heparin derivatives or fragments are exemplary NE-targeting agents. The compositions preferably include a carrier, such as chitosan, to facilitate delivery of the active agent. Methods of manufacturing non-anticoagulant heparin are also provided. Methods of administering the disclosed compositions to treat respiratory diseases are also disclosed. In preferred methods, an effective amount of the pharmaceutical composition is administered to subject in need thereof to reduce, inhibit, or alleviate one or more symptoms of chronic respiratory inflammation. In the most preferred embodiment, the composition is administered as a dry powder, intranasally or by inhalation.

Supplementary Information

Patent Number: US20110212181A1
Application Number: US13035414A
Inventor: Shum, Daisy Kwok Yan | Ip, Mary Sau Man | Chan, Chi Hang | Leung, Valeria On Yue
Priority Date: 26 Feb 2010
Priority Number: US20110212181A1
Application Date: 25 Feb 2011
Publication Date: 1 Sep 2011
IPC Current: A61K000914 | A61K0031727 | A61P001100 | C08B003710
US Class: 424493 | 424499 | 514056 | 536021
Assignee Applicant: The University of Hong Kong
Title: COMPOSITIONS AND METHODS FOR TREATING CHRONIC RESPIRATORY INFLAMMATION
Usefulness: COMPOSITIONS AND METHODS FOR TREATING CHRONIC RESPIRATORY INFLAMMATION
Summary: The composition is useful for treating a respiratory disease or disorder, such as one or more symptom of chronic respiratory inflammation and chronic respiratory inflammation including bronchiectasis, emphysema and chronic obstructive pulmonary disease, where the symptoms are prolonged or abnormal inflammation, permanently dilated bronchi, airflow limitation, chronic cough, sputum production, hemoptysis, dyspnea, air trapping, wheezing, chest pain or recurrent lung infection (all claimed). The composition is useful for treating e.g. vascular diseases including systemic lupus erythematosus, rheumatoid arthritis, scleroderma, dermatomyositis, mixed connective tissue disorder, vasculitis and sarcoid. Tests details are described but no results given.
Novelty: Composition, useful for treating respiratory disease e.g. chronic respiratory inflammation e.g. bronchiectasis and chronic obstructive pulmonary disease, comprises a agent to decrease neutrophil elastase activity in subject

Industry

Biomedical

Sub Category

Medical Composition

Application No.

US13035414A

Country/Region

Hong Kong