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Uses of Dinucleotide Polyphosphate Derivatives

Summary

The present invention provides the use of analogues and derivatives of dinucleoside polyphosphates with formula (I) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in one or more of: the treatment of ischemia, inducing ischemic tolerance, modulating cerebral ischemia, to delay the onset of a hypoxic depolarisation stage when ischemic events are initiated; as a neurological protection agent; as a tissue protection agent; the treatment of pain; and the treatment of inflammation, wherein X, is selected from wherein X1 and X2 are independently selected from H, Cl, Br and F; each Y is independently selected from S and O; each Z is independently selected from -CX3X4-,-NH-,-O-; wherein X3 and X4 are selected from H, Cl, Br and F; B1 and B2 are independently selected from adenine, guanine, xanthine, thymine, uracil, cytosine and inosine; S1 and S2 are independently selected from ribose, open chain ribose, 2'-deoxyribose, 3'deoxyribose and arabinofuranoside. V is selected from 0, 1, 2, 3, 4 and 5; W is selected from 0, 1, 2, 3, 4 and 5; and V plus W is an integer from 2 to 6.

Supplementary Information

Inventor: Miller, Andrew David | Wright, Michael | Tanner, Julian Alexander | Lozovaya, Natalya
Priority Number: US20080319184A1
IPC Current: C07H002102 | A61K00317084 | C07H002100 | C07H002104
US Class: 53602626
Title: Uses of Dinucleotide Polyphosphate Derivatives
Usefulness: Uses of Dinucleotide Polyphosphate Derivatives
Summary: As a neurological protection agent; as a tissue protection agent and in manufacture of a medicament for treatment of ischemia, pain, inflammation (claimed), spinal injuries, head trauma, myocardial ischemia, cardiovascular diseases, hypertension, angina, arrhythmia, thrombosis, embolism, chronic or acute congestive heart failure, peripheral vascular disease, intermittent claudication, spasms of smooth muscle, ureter, bladder, uterine cramps, irritable bowel syndrome, vasoconstriction, ischemic tissue damage during a surgical procedure, neurological diseases, brain trauma, brain or cerebrovascular ischemia, neurodegenerative diseases, poisoning of neuronal cells, preservation of neuronal grafts, hyperalgesia, amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, rheumatoid arthritis, osteoarthritis, pain associated with cancer, post-operative and postpartum pain, pain associated with dental conditions such as dental caries and gingivitis, sunburn, bone disorders, osteoporosis, hypercalcaemia of malignancy, Paget's disease, sports injuries, sprains, arthritis, myocarditis, encephalitis, transplant rejection, systemic lupus erythematosus, gout, dermatitis, inflammatory bowel disease, hepatitis, thyroiditis and stress.
Novelty: Use of analogs and derivatives of dinucleoside polyphosphates for treating e.g. ischemia, pain, inflammation or as neurological protection agent and tissue protection agent

Industry

Biomedical

Sub Category

Medical Composition

Application No.

US2007883661A

Country/Region

Hong Kong