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Procollagen IIA deficient mice

Summary

This invention relates to the production of dual models of Congenital Heart Defects and Hypertrophic Cardiomyopathy with the use of mice which are genetically modified by transgenic (gene-knockout) techniques. The present invention produces knockout mice that show multiple cardiovascular malformations which will serve as a model of cardiovascular diseases for the screening of potential drugs against ventricular remodeling, malignant arrhythmias, primary pulmonary hypertension, and degenerative valvular diseases, and congenital heart disease.

Supplementary Information

Patent Number: GB2431657B
Application Number: GB20071369A
Inventor: CHEAH, SONGENG KATHRYN | ZHANG, LINCHYNGJIAN JANET
Priority Date: 26 Jul 2004
Priority Number: GB2431657B
Application Date: 25 Jul 2005
Publication Date: 6 Jan 2010
IPC Current: A01K0067027 | C07K001478 | C12N001585 | G01N003350
Assignee Applicant: The University of Hong Kong
Title: Procollagen IIA Deficient Mice
Usefulness: Procollagen IIA Deficient Mice
Summary: (M1) is useful for producing mutant Col2A-1 transgenic mouse. (M2) is useful for producing a mutant mouse. (I) is useful for screening agents for treatment of a selected cardiac disorder, where the selected cardiac disorders include sudden cardiac death, cardiomegaly, cardiomyocyte, hypertrophy, cellular disarray, pulmonary hypertension with right ventricular hypertrophy, and valvular fibrosis (all claimed). (M1) is useful for screening potential drugs against ventricular remodeling, malignant arrhythmias, and congenital heart disease.
Novelty: Producing mutant procollagen IIA (Col2A-1) transgenic mouse, by introducing selected mouse embryonic stem cells having mutant Col2A-1 transgene into mouse blastocysts, and crossing chimeric founder transgenic mouse with wild-type mouse

Industry

Biomedical

Sub Group

DNA/Gene Engineering

Country/Region

Hong Kong

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