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METHOD FOR ISOLATING CIMIRACEMATE A

Summary

The subject invention provides a method for optimal isolation of cimiracemate A for subsequent use as a therapeutic agent or dietary supplement in single entry or in combination with other treatment modalities. In addition, the subject invention discloses cimiracemate A as a bioactive marker that can be used to identify the members of the Cimicifuga genus for example: C. racemosa, C. dahitrica (Turcz.) Maxim., C. foetida L., and C. heracleifolia Kom. The bioactive marker cimiracemate A can also be used to standardize the extracts of C. racemosa as anti-inflammatory agents for the treatment of inflammatory conditions associated with diseases and syndromes including, for example, rheumatism, stroke, myocarditis, atherosclerosis, infectious diseases, allergy and related autoimmune diseases.

Supplementary Information

Inventor: Yang, Lai Hung Cindy | Lau, Allan Sy
Priority Number: AU2010264200B2
IPC Current: C07C003921 | A61K003105 | A61K003628 | A61K003671
Assignee Applicant: BAGI Research Limited | Versitech Limited
Title: Method for isolating cimiracemate A
Usefulness: Method for isolating cimiracemate A
Summary: The cimiracemate A is useful: as a therapeutic composition, a dietary supplement, a bioactive chemical marker and standard for various species of Cimicifuga . The cimiracemate A is useful for treating malaise, malaria, rheumatism, abnormal kidney function, sore throat, menstrual irregularities, diseases associated with childbirth, fever, headache pain, and chills. The cimiracemate A is useful to suppress lipopolysaccharide-induced TNFα in human macrophages, and as a reactive oxygen species scavenger. No biological data given.
Novelty: Isolating cimiracemate A from Cimicifuga species, comprises providing raw material of Cimicifuga species, mixing the raw material of Cimicifuga species with aqueous polar solvent and isolating cimiracemate A from obtained solvent extract

Industry

Biomedical

Sub Group

Pharmaceuticals

Country/Region

Hong Kong

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