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Baicalin and its derivatives as a treatment for SARS coronavirus infection or other related infections

Summary: The present invention relates to a pharmaceutical composition useful for the treatment of diseases associated with viruses of the order Nidovirales of the family Coronaviradae, such as Severe Acute Respiratory Syndrome (SARS) viruses in humans and other animals. In particular, this invention relates to a naturally occurring compound, namely, baicalin, extracted and purified from the Chinese medicinal plant Scutellaria baicalensis Georgi (Chinese name: Huang Qin), that exhibits potent antiviral activity against members of the order Nidovirales of the family Coronaviradae that infects humans and other animals; in particular, SARS viruses in humans ("hSARS virus").; The invention also relates to a therapeutic method, using pharmaceutical compositions comprising baicalin compounds, for the treatment, amelioration, management or prevention of diseases associated with members of the order Nidovirales of the family Coronaviradae, such as hSARS.

Supplementary Information: Patent Number: CN1901921A
Application Number: CN200480040083A
Inventor: YUEN KWOKYUNG | CHEN FENG | CHAN KWOKHUNG | KAO YITSUN | GUAN YI | POON LITMAN LEO | PEIRIS J S M
Priority Date: 10 Nov 2003
Priority Number: CN1901921A
Application Date: 10 Nov 2004
Publication Date: 24 Jan 2007
IPC Current: A61K00317048 | A61K0031382 | A61P003112
Assignee Applicant: The University of Hong Kong
Title: Baicalin and its derivatives as a treatment for SARS coronavirus infection or other related infections
Usefulness: Baicalin and its derivatives as a treatment for SARS coronavirus infection or other related infections
Summary: (A) is useful for the treatment of diseases associated with a virus (human severe acute respiratory syndrome (hSARS) virus) that belongs to the order nidovirales of the family coronaviridae in human (claimed).
Novelty: Composition, useful for the treatment of diseases associated with virus that belongs to the order nidovirales of the family Coronaviridae, comprises baicalin compounds

Industry: Chemical/Material

Sub Category: Chemical/Material Application

Application No.: CN200480040083A

Country/Region: Hong Kong

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