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Non-Invasive Methods For Detecting Non-Host Dna In A Host Using Epigenetic Differences Between The Host And Non-Host Dna

Summary
本项目是以数据建模、实时通信、虚拟现实、应用集成等技术为支撑,开发完成的国内具有自主知识产权的复杂产品虚拟试验支撑平台,主要由试验方案动态生成子系统、试验过程控制子系统、试验过程可视化子系统、试验数据管理子系统、试验数据分析子系统五个子系统构成,在虚拟试验体系构建方法、虚拟试验支撑平台开发、虚拟试验应用系统构建、虚拟试验模型验证和分析方法等方面具有创新。本项目的应用可有效弥补复杂产品小子样实物试验带来的验证局限性,模拟无法在真实条件下进行的系统级虚拟试验验证,在多次实物试验的基础上建立复杂产品虚拟试验模型,为全面考核复杂产品的设计性能提供试验数据和分析手段。
本项目突破了多项关键技术,并已形成原型系统,于2011 年12 月以优秀的成绩通过了国防科工局项目验收,软件安装包、使用文档齐全,具备了在行业内进行应用推广的条件。在本项目基础上,以航天系统型号复杂产品设计为应用背景,构建了多个虚拟试验应用系统,完成了虚拟试验“模型、数据、过程”的管理和驱动,初步实现了虚拟试验数据和实物试验数据的有机结合。本项目在航天一院12 所、15所、702 所以及六院101所等单位得到应用,得到了航天系统内多家单位的认可。相关技术成果获国防科技进步三等奖一项、国家科技进步二等奖一项。潜在受让方为航空、航天等复杂产品研发单位的先进制造领域应用。
本项目填补国内在虚拟试验领域支撑平台产品领域的空白,突破了国外发达国家对相关技术和产品的技术封锁,各项功能指标、技术指标达到国内外领先水平。
知识产权状况及获奖情况:
1、一种虚拟试验数据对象化管理系统 ZL201010240156.9
2、一种实物设备与数学模型联合试验系统及方法 ZL201110268323.5
3、一种基于HLA的通用分布式视景仿真系统及实现方法 ZL200910078265.2
4、用于集成优化软件的通用接口系统 ZL200910243286.5
Supplementary Information
Patent Number: US6927028B2
Application Number: US2001944951A
Inventor: Dennis, Lo Yuk Ming | Man, Poon Lit
Priority Date: 31 Aug 2001
Priority Number: US6927028B2
Application Date: 31 Aug 2001
Publication Date: 9 Aug 2005
IPC Current: G01N003350 | C12N001509 | C12Q000168
US Class: 43500611 | 435006 | 435004 | 4350911 | 4350912 | 5360231 | 5360243
Assignee Applicant: The Chinese University of Hong Kong
Title: Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
Usefulness: Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
Summary: The method is useful in detecting DNA originating from different individuals, such as in differentiating or detecting fetal DNA in a maternal sample or differentiating DNA of an organ donor from that of an organ recipient. The method may be used in detecting genetic abnormalities in a fetus.
Novelty: Differentiating DNA species originating from different individuals in a biological sample, useful for detecting genetic abnormalities in a fetus, comprises determining epigenetic differences between these DNA species
Industry
Biomedical
Sub Category
DNA/Gene Engineering
Application No.
1. 一种虚拟试验数据对象化管理系统 ZL201010240156.9
2. 一种实物设备与数学模型联合试验系统及方法 ZL201110268323.5
3. 一种基于HLA的通用分布式视景仿真系统及实现方法 ZL200910078265.2
4. 用于集成优化软件的通用接口系统 ZL200910243286.5
Country/Region
Hong Kong

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