Method for Creating Intracellular Artificial Nanostructures in Situ催化反應誘導自組裝形成細胞內納米結構及其對細胞的功能控制
- Summary
- The present invention provides a method for controlling the fate of mammalian cells or microorganisms by the enzymatic formation of intracellular nanostructures. Enzymatic reactions trigger the intracellular self-assembly to convert a proper precursor into another molecule or nanoobject that will aggregate inside cells or inside or between tissues or organs. Further, this invention provides a method for making artificial nanostructures inside or between tissues or organs, by injecting a proper designed precursor into tissues or organs, and enzymatic reaction converting the precursor to a hydrogelator to form artificial nanostructures and inducing hydrogelation and at the state of a disease, another enzyme converts the hydrogelator back to precursor to induce gel-to-sol transition to release a drug.
- Technology Benefits
- 1. Intracellular artificial nanostructures provide an attractive and effective strategy from perturbing the
cellular activities to managing the behaviors of cells
2. Intracellular artificial nanostructures offers a versatile platform for mimicking, modeling, and
understanding the mechanism of diseases, thus developing the therapeutic approaches
- Technology Application
- - The present invention can be applied to treat diseases caused by the malfunction of cells, infection caused by microorganisms and provides a novel route for controlled drug releases, formation of new therapeutic agents, and in-situ formation of hydrogel to treat degenerative diseases such as osteoarthritis
- Supplementary Information
- Patent Number: US8338151B2
Application Number: US2008194554A
Inventor: Xu, Bing | Yang, Zhimou | Xu, Keming
Priority Date: 8 Aug 2005
Priority Number: US8338151B2
Application Date: 20 Aug 2008
Publication Date: 25 Dec 2012
IPC Current: C12N000104 | C12N000900
US Class: 435183 | 424484 | 424488 | 435243 | 435325
Assignee Applicant: The Hong Kong University of Science & Technology
Title: Method for creating intracellular artificial nanostructures in situ
Usefulness: Method for creating intracellular artificial nanostructures in situ
Summary: (I) is useful to provide controlled drug releases; form new therapeutic agents; and form hydrogels to treat chronic diseases such as osteoarthritis. The precursor is useful to treat/prevent cancer, diabetes, Alzheimer's disease, multiple sclerosis and osteoarthritis (all claimed).
Novelty: Making intracellular artificial nanostructures, useful to treat osteoarthritis, comprises contacting proper design precursor with cells/microorganisms; and placing cells/microorganisms to permit precursor into nanostructures
- Industry
- Disease Diagnostic/Treatment
- Sub Category
- Cancer/Tumor
- Application Date
- 20 Aug 2008
- Application No.
- US 12/194554
- Patent Information
- US 8338151
- ID No.
- TTC.PA.266S
- Country/Region
- Hong Kong
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