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p35nck5a Binding Proteins

Summary: Cyclin-dependent protein kinase 5 (Cdk5) has been shown to be involved in neuronal cell differentiation in the form of an active kinase, named neuronal Cdc2-like kinase (Nclk). However, its activity was shown to be suppressed by forming complex with p35^nck5a. Therefore, there is a need for identifying the identities of various binding proteins in the macromolecular protein complex.

The present inventors have now succeeded in isolating three novel p35^nck5a binding proteins useful for a variety of purposes, particularly as tools to analyze how p35nck5a interacts with other proteins and for drug development for Alzheimer's Disease.

This invention provides a method to screen a large number of molecules or compounds for their ability to form complexes with the p35^nck5a binding protein of the invention. It also provides a method of using the p35^nck5a binding protein of the invention to purify a molecule or compound which specifically binds the p35^nck5a binding protein of the invention.

Technology Benefits: 1. Novel

Technology Application: - Potential molecular target for designing new drugs to tackle the Alzheimer's Disease
- Delineating the signal transduction pathway by which Nclk exert its effects
- Useful for designing new drugs that may modulate Nclk activity within the cell

Supplementary Information: Patent Number: US6753413B1
Application Number: US2000652603A
Inventor: Ching, Yick Pang | Wang, Jerry H. C.
Priority Date: 30 Aug 1999
Priority Number: US6753413B1
Application Date: 30 Aug 2000
Publication Date: 22 Jun 2004
IPC Current: C07K001447
US Class: 530352
Assignee Applicant: The Hong Kong University of Science & Technology
Title: P35NCK5A binding proteins
Usefulness: P35NCK5A binding proteins
Summary: For analyzing how p35-nck5a interacts with other proteins and for purifying a molecule or compound (e.g. peptide, agonist, antagonist, inhibitor, antibody, pharmaceutical agent) which specifically binds the p35-nck5a binding protein.
Novelty: New p35-nck5a binding protein for analyzing how p35-nck5a interacts with other proteins and for purifying molecule or compound, e.g. peptide, agonist, antagonist, inhibitor, antibody, pharmaceutical agent

Industry: Chemical/Material

Sub Category: Chemical/Material Application

Application Date: 30 Aug 2000

Application No.: US 09/652603

Patent Information: US 6753413

ID No.: TTC.PA.127

Country/Region: Hong Kong

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