Pulmonary Drug Delivery System
One of the known routes for the delivery of drugs into the human or animal body is pulmonary drug delivery, for example through nasal sprays or tracheal instillation. However, such method is very wasteful and a relatively large amount of the drug is necessary to ensure that the correct dose is received by the patient.
A novel technique has been developed for pulmonary drug delivery. An effective amount of a pharmaceutically active agent in the solution mixed directly with physiologically acceptable surfactant has been found to significantly increase the absorption of the pharmaceutically active agent via the pulmonary route.
This invention is particularly applicable to the delivery of drugs which cannot be given orally, or which have localized action in the lung. In particular the invention may be applied to the delivery of protein-based drugs such as insulin using for therapeutic treatment of diabetes mellitus.
The invention also extends to a method for the manufacture of pharmaceutical composition, comprising the pulmonary delivery of an effective amount of a pharmaceutically active agent mixed directly with a physiologically acceptable surfactant.
1. Chronic disease can be treated with pulmonary drug delivery
2. Drugs which cannot be given orally, can be delivered
3. It can increase the absorption of drug via pulmonary drug delivery
- Anti tumor agents for therapeutic treatment of lung cancer
- Therapeutic treatment of chronic diseases such as diabetes mellitus
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Patent Number: US5451569A
Application Number: US1994229600A
Inventor: Wong, Jeffrey T. F. | Tam, Michael S. C.
Priority Date: 19 Apr 1994
Priority Number: US5451569A
Application Date: 19 Apr 1994
Publication Date: 19 Sep 1995
IPC Current: A61K000900 | A61K000908 | A61K003811 | A61K003828 | A61K004508
US Class: 5140065 | 514003 | 5140011 | 5140109 | 5140155 | 514807 | 514975
Assignee Applicant: The Hong Kong University of Science & Technology
Title: Pulmonary drug delivery system
Usefulness: Pulmonary drug delivery system
Summary: USE The compsn. can be admin. by e.g., nasal spray or tracheal instillation, and is partic useful for agents which cannot be given orally, including those poorly absorbed, those degraded in the GI tract, and those causing irritation. The agents include partic. proteins and peptides, e.g. insulin tricosanthin, and vasopressin.
Novelty: Pulmonary drug delivery system using pulmonary surfactant provides efficient, convenient absorption, use partic. for proteins and peptides, e.g., insulin, tricosanthin, and vasopressin.
Biomedical
Medical Composition
19 Apr 1994
US 5451569
TTC.PA.003
Hong Kong
