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Antibacterial Agents Against Methicilin- and Vancomycin-Resistant Bacteria

Summary

Researchers at Purdue University have identified compounds with potent antibacterial activities. The most potent compounds inhibited growth of various-resistant Gram-positive bacterial pathogens. Some compounds were active against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus (VISA and VRSA respectively), and vancomycin-resistant Enterococcus faecalis (VRE). Through resistance generation experiments it was revealed that MRSA could not develop resistance to one of these compounds.

Technology Benefits

Compounds can kill methicillin and vancomycin-resistant bacteriaNo resistance from MRSAPotent activity against drug-resistant Gram-positive pathogens

Technology Application

Pharmaceuticals/biotech companiesAnimal medicineBacterial burden in skin wound infections

Detailed Technology Description

Herman SintimSintim Research GroupPurdue Chemistry

Countries

United States

Application No.

None

Country/Region

USA

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