Antibacterial Agents Against Methicilin- and Vancomycin-Resistant Bacteria
- 总结
- Researchers at Purdue University have identified compounds with potent antibacterial activities. The most potent compounds inhibited growth of various-resistant Gram-positive bacterial pathogens. Some compounds were active against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus (VISA and VRSA respectively), and vancomycin-resistant Enterococcus faecalis (VRE). Through resistance generation experiments it was revealed that MRSA could not develop resistance to one of these compounds.
- 技术优势
- Compounds can kill methicillin and vancomycin-resistant bacteriaNo resistance from MRSAPotent activity against drug-resistant Gram-positive pathogens
- 技术应用
- Pharmaceuticals/biotech companiesAnimal medicineBacterial burden in skin wound infections
- 详细技术说明
- Herman SintimSintim Research GroupPurdue Chemistry
- *Abstract
-
None
- *Background
- The discovery and development of antibiotics revolutionized health care in such a way that bacterial infections, which were otherwise deadly, could be treated; however, this was met with a rapid development of resistant bacterial strains that rendered many antibiotics ineffective. Consequently, millions of people are infected with drug-resistant bacterial strains yearly resulting in thousands of deaths. Efforts need to be directed towards identifying and developing novel structures as antibacterial agents with possibly novel mechanisms of action.
- *IP Issue Date
- None
- *IP Type
- Provisional
- *Publications
- Clement Opoku-Temeng et al., N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteriaEuropean Journal of Medicinal Chemistry, 2018https://doi.org/10.1016/j.ejmech.2018.06.023
- *Stage of Development
- Concept validated through theory, simulation, or models
- *Web Links
- Purdue Office of Technology CommercializationPurdue Innovation and EntrepreneurshipHerman SintimSintim Research GroupPurdue Chemistry
- 国家
- United States
- 申请号码
- None
- 国家/地区
- 美国
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