Anti-Schistosoma mansoni Circulating Cathodic Antigen (CCA) Monoclonal Antibody (3 lines)
- Detailed Technology Description
- ApplicationsValidated for ELISA applications.Schistosoma mansoni is one of threeparasitic neglected tropical diseases that causes Schistosomiasis. Infectionoccurs when skin comes in contact with contaminated freshwater in which certaintypes of snails that carry schistosomes are living. Circulating CathodicAntigen (CCA) can be used as a diagnostic tool by being present in urine ininfected patients with S. mansoni. an anti-CirculatingCathodic Antigen (CCA) monoclonal antibody that binds to this circulatingantigen in serum from individuals with a low level of infection of Schistosomamansoni, and does not cross-react with Lewis x epitope. Validated as aqualitative and quantitative method for the diagnosis of S. mansoni in individuals with very low level / pre-symptomaticinfection by S. mansoni.
- *Abstract
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ReagentDescription
Reacts with and strongly binds to CCA of S. mansoni. Very sensitive to even lowlevels of infection.
Antigen:
Circulating Cathodic Antigen (CCA) of Schistosoma mansoni
Clonality:
Monoclonal
Clone Name:
12D3.F2 (IgM); 16D7.C10 (IgM); 5F4.B4 (IgG1k)
Reactivity:
S. mansoni
Immunogen:
Protein/peptide
Species Immunized:
Mouse
Purification Method:
Protein G
Buffer:
Cell culture supernatant
Tested Applications:
ELISA
References
Grenfell RF,Coelho PM, Taboada D, de Mattos AC, Davis R, Harn DA. Newlyestablished monoclonal antibody diagnostic assays for Schistosoma mansonidirect detection in areas of low endemicity. PLoS One. 2014 Jan 31;9(1):e87777
Grenfell R,Harn DA, Tundup S, Da'dara A, Siqueira L, Coelho PM. Newapproaches with different types of circulating cathodic antigen for thediagnosis of patients with low Schistosoma mansoni load. PLoS Negl Trop Dis.2013;7(2):e2054
- Country/Region
- USA
