Microglia Induce Motor Neuron Death via the Classical NF-kB Pathway in Amyotrophic lateral sclerosis (ALS)
- Detailed Technology Description
- Researchers at Nationwide Children's Hospital have demonstrated a new therapeutic target to modulate microglial activation and slow the progression of ALS and other neurodegenerative diseases in which microglial activation plays a role.
- Countries
- Not Available
- Application No.
- None
- *Abstract
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Nuclear Factor-kappa B (NF-κB) is amaster regulator of inflammation and is upregulated in the spinal cord of ALSpatients and in ALS mice models. Researchers at Nationwide Children's Hospitalhave demonstrated that NF-kB inhibition in ALS microglia rescued motor neurons(MNs) from microglia-mediated death in vitro and extended survival inALS mice by impairing pro-inflammatory microglial activation. This work for the first time provides acellular and molecular mechanism by which microglia induce motor neuron deathin ALS and suggests a new therapeutic target to modulate microglialactivation and slow the progression of ALS and other neurodegenerative diseasesin which microglial activation plays a role.
- *Inquiry
- Margaret Barkett, Ph.D.The Research Institute at Nationwide Children's HospitalOffice of Technology Commercialization700 Children's Drive Columbus OH 43205T: 614 355-2957 F: 614 722-2716Margaret.Barkett@nationwidechildrens.org
- *IP Issue Date
- None
- *IP Type
- Other Patent
- Country/Region
- USA
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