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Microglia Induce Motor Neuron Death via the Classical NF-kB Pathway in Amyotrophic lateral sclerosis (ALS)

详细技术说明

Researchers at Nationwide Children's Hospital have demonstrated a new therapeutic target to modulate microglial activation and slow the progression of ALS and other neurodegenerative diseases in which microglial activation plays a role.

*Abstract

Nuclear Factor-kappa B (NF-κB) is amaster regulator of inflammation and is upregulated in the spinal cord of ALSpatients and in ALS mice models. Researchers at Nationwide Children's Hospitalhave demonstrated that NF-kB inhibition in ALS microglia rescued motor neurons(MNs) from microglia-mediated death in vitro and extended survival inALS mice by impairing pro-inflammatory microglial activation. This work for the first time provides acellular and molecular mechanism by which microglia induce motor neuron deathin ALS and suggests a new therapeutic target to modulate microglialactivation and slow the progression of ALS and other neurodegenerative diseasesin which microglial activation plays a role.   

*Inquiry

Margaret Barkett, Ph.D.The Research Institute at Nationwide Children's HospitalOffice of Technology Commercialization700 Children's Drive Columbus OH 43205T: 614 355-2957 F: 614 722-2716Margaret.Barkett@nationwidechildrens.org

*IP Issue Date

None

*IP Type

Other Patent

国家

Not Available

申请号码

None

国家/地区

美国