Pseudoprolines in Neuropeptides

Title: Development of Novel Pseudopeptides  Invention: The invention describes the use of pseudo peptides to cross the blood-brain barrier and bind to targeted receptors to achieve pharmaceutical effects.  Background: Increased research has led to the exploration of peptides delivering compounds by diffusing across the blood-brain barrier. Many peptide-based drugs are not created using pseudo-peptides, however, glycosylation plays a key role in manipulating the structure of existing peptides. This invention uses glycosylation to create a newly folded peptide that can then be used in a variety of pharmaceutical applications to produce medicinal effects.  Applications: Targeted drug deliveryBiosensors Diagnostic imaging Advantages: Increased capability to cross the blood-brain barrier Increased affinity to bind to specific targeted receptors Breakdown of the compound may not yield any toxic effects  Licensing Manager:Laura SilvaLauraS@tla.arizona.edu(520) 626-1557

USA