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Bio-electrochemical Sensor for Real-time, In Vivo Clinical Tests

Technology Benefits

Monitors continuously and in real-time for over 5 hours with no significant signal degradationMinimally invasive, sub-millimeter-diameter probe Membrane technology prevents fouling by blood cells

Technology Application

In vivo and in vitro clinical testingStudy of patient-dependent pharmacokinetics Study of neuromodulation dynamics

Detailed Technology Description

UC Santa Barbara researchers have developed a minimally invasive, bio-electrochemical sensor for in vivo clinical tests that selectively measure specific target molecules in blood and tissues in real-time for many hours. The use of membrane technology prevents contact between blood cells and the surface of the sensor, therefore stopping blood clotting and blood or tissue-associated signal degradation over time. The sensor relies on E-AB (electrochemical aptamer-based) sensing, uses flexible and biocompatible materials, and is designed for both short-term and long-term clinical testing.

Others

Background

The continuous, real-time measurement of specific small molecules in the blood or tissues would be of significant value to researchers and clinicians alike. To achieve improved understanding of neuronal transmission, for example, will require technologies that can measure neurotransmitters and drugs directly in the central nervous system continuously and with good temporal and concentration resolution. Continuous, real-time, highly resolved monitoring of specific molecules in vivo, however, remains a great challenge.

Additional Technologies by these Inventors

• Fluorescent and Electrochemical DNA-Based Switches for Antibody Detection
• Dual-Labeled E-AB Platform for Continuous, Real-Time Monitoring of Small Molecules
• Drift-Free, Self-Calibrated Interrogation Method For Electrochemical Sensors Based On Electron Transfer Kinetics
• Drift-Free and Calibration-Free Measurement of Analytes

Tech ID/UC Case

25593/2016-135-0

Related Cases

2016-135-0

*Abstract

A minimally invasive, bio-electrochemical sensor for in vivo clinical tests that selectively measures specific target molecules in blood and tissues in real-time for many hours.

*Principal Investigator

Name: Netzahualcoyotl Arroyo Curras

Department:

Name: Jacob Somerson

Department:

Name: Kevin Plaxco

Department:

Country/Region

USA