Vaccines Against Acne and Acne-Associated Diseases
- Technology Benefits
- In addition to treating acne vulgaris, an anti-P. acnes vaccine could benefit human polymicrobial P. acnes associated diseases, including endocarditis, endophthalmitis, osteomyelitis, joint, nervous system, cranial neurosurgery infections, and implanted biomaterial contamination. Treatment of acne should be started as early as possible to minimize the risk of scarring and adverse psychological effects. Development of anti-acne vaccines may be able to prevent acne progression from the early stages and increase the specificity of treatments.
- Detailed Technology Description
- UC San Diego investigators have demonstrated a strategy to create anti-P. acnes vaccines targeting the secreted antigen CAMP factor. The vaccine was effective in an animal model both prophylactically and immunotherapeutically. Developing P. acnes vaccines could be an effective strategy to decrease P. acnes-induced inflammation.
- Supplementary Information
- Patent Number: US20110243960A1
Application Number: US13132905A
Inventor: Gallo, Richard L. | Huang, Chun-Ming
Priority Date: 5 Dec 2008
Priority Number: US20110243960A1
Application Date: 3 Jun 2011
Publication Date: 6 Oct 2011
IPC Current: A61K003940 | A61K003902 | A61P002900 | A61P003104 | A61P003704 | C07D022328 | C07K000706 | C07K000708 | C07K0014195 | C07K001640 | C12N000916 | C12N000924 | C12N001563
US Class: 4241581 | 4242341 | 435196 | 435200 | 4353201 | 530327 | 530328 | 530350 | 5303895 | 540592
Assignee Applicant: The Regents of the University of California
Title: METHODS AND COMPOSITIONS FOR TREATING P. ACNES
Usefulness: METHODS AND COMPOSITIONS FOR TREATING P. ACNES
Summary: For inducing protective immunity against P. acnes in a subject; protecting susceptible host against an infection of P. acnes ; and treating P. acnes (claimed).
Novelty: Immunogenic composition for inducing protective immunity against Propionibacterium acnes and Streptococcus aureus comprises purified polypeptide comprising specific secretory virulence factors, membrane proteins, enzymes and other proteins
- Industry
- Biomedical
- Sub Category
- Pathogen
- Application No.
- 9340769
- Others
-
State Of Development
In vitro data and animal models.
Other Information
This technology is available for licensing
Related Materials
- Nakatsuji T, Liu YT, Huang CP, Gallo RL, Huang CM. Antibodies Elicited by Inactivated Propionibacterium Acnes-Based Vaccines Exert Protective Immunity and Attenuate the IL-8 Production in Human Sebocytes: Relevance to Therapy for Acne Vulgaris. J Invest Dermatol. 2008 May 8.
- Nakatsuji T, Liu YT, Huang CP, Gallo RL, Huang CM. Vaccination Targeting a Surface Sialidase of P. acnes: Implication for New Treatment of Acne Vulgaris. PLoS ONE. 2008 Feb 6;3(2):e1551.
- Acne vaccines targeting Propionibacterium acnes. Kao M, Huang CM. G Ital Dermatol Venereol. 2009 Dec;144(6):639-43.
Commercial Use
Development of anti-acne vaccines may be able to prevent acne progression from the early stages and increase the specificity of treatments.
Tech ID/UC Case
19417/2009-183-0
Related Cases
2009-183-0
- *Abstract
-
Propionibacterium acnes (P. acnes) bacteria is involved in many human polymicrobial diseases. It is the causative agent in acne vulgaris, a human polymicrobial disease. Acne vulgaris is the most common skin disease, affecting more than 85 percent of people at some time during their lives and currently affects more than fifty million people in the U.S. Current antibiotic therapy for acne lesions provides a non-specific treatment that kills the majority of skin bacteria and impacts the homeostasis of skin- and intestinal-resident flora.
Acne vulgaris can result in severe inflammatory lesions that are highly associated with P. acnes infection. There are no appropriate therapeutic modalities that are long-lasting and systemically effective and that specifically suppress P. acnes-induced pathogenesis and inflammation. In addition, these bacteria have the ability to trigger inflammatory responses. Many antibiotics have been used for acne treatment, but these antibiotics in general are non-specific, short lasting, and normally are applied when acne lesions have already occurred (such as in late stages of acne). Available topical treatments for acne lesions, including drugs, are palliative and effective only while treatment is maintained. When treatment is discontinued, increased acne gain inevitably results.
- *IP Issue Date
- May 17, 2016
- *Principal Investigator
-
Name: Richard Gallo
Department:
Name: Richard Gallo
Department:
Name: Chun-Ming Eric Huang
Department:
Name: Chun-Ming Eric Huang
Department:
- Country/Region
- USA
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