Vaccines Against Acne and Acne-Associated Diseases

In addition to treating acne vulgaris, an anti-P. acnes vaccine could benefit human polymicrobial P. acnes associated diseases, including endocarditis, endophthalmitis, osteomyelitis, joint, nervous system, cranial neurosurgery infections, and implanted biomaterial contamination. Treatment of acne should be started as early as possible to minimize the risk of scarring and adverse psychological effects. Development of anti-acne vaccines may be able to prevent acne progression from the early stages and increase the specificity of treatments.

UC San Diego investigators have demonstrated a strategy to create anti-P. acnes vaccines targeting the secreted antigen CAMP factor. The vaccine was effective in an animal model both prophylactically and immunotherapeutically. Developing P. acnes vaccines could be an effective strategy to decrease P. acnes-induced inflammation.

Patent Number: US20110243960A1
Application Number: US13132905A
Inventor: Gallo, Richard L. | Huang, Chun-Ming
Priority Date: 5 Dec 2008
Priority Number: US20110243960A1
Application Date: 3 Jun 2011
Publication Date: 6 Oct 2011
IPC Current: A61K003940 | A61K003902 | A61P002900 | A61P003104 | A61P003704 | C07D022328 | C07K000706 | C07K000708 | C07K0014195 | C07K001640 | C12N000916 | C12N000924 | C12N001563
US Class: 4241581 | 4242341 | 435196 | 435200 | 4353201 | 530327 | 530328 | 530350 | 5303895 | 540592
Assignee Applicant: The Regents of the University of California
Title: METHODS AND COMPOSITIONS FOR TREATING P. ACNES
Usefulness: METHODS AND COMPOSITIONS FOR TREATING P. ACNES
Summary: For inducing protective immunity against P. acnes in a subject; protecting susceptible host against an infection of P. acnes ; and treating P. acnes (claimed).
Novelty: Immunogenic composition for inducing protective immunity against Propionibacterium acnes and Streptococcus aureus comprises purified polypeptide comprising specific secretory virulence factors, membrane proteins, enzymes and other proteins

生物医学

病原

9340769

State Of Development

In vitro data and animal models.

Other Information

This technology is available for licensing

Related Materials

1. Nakatsuji T, Liu YT, Huang CP, Gallo RL, Huang CM. Antibodies Elicited by Inactivated Propionibacterium Acnes-Based Vaccines Exert Protective Immunity and Attenuate the IL-8 Production in Human Sebocytes: Relevance to Therapy for Acne Vulgaris. J Invest Dermatol. 2008 May 8.
2. Nakatsuji T, Liu YT, Huang CP, Gallo RL, Huang CM. Vaccination Targeting a Surface Sialidase of P. acnes: Implication for New Treatment of Acne Vulgaris. PLoS ONE. 2008 Feb 6;3(2):e1551.
3. Acne vaccines targeting Propionibacterium acnes. Kao M, Huang CM. G Ital Dermatol Venereol. 2009 Dec;144(6):639-43.

Commercial Use

Development of anti-acne vaccines may be able to prevent acne progression from the early stages and increase the specificity of treatments.

Tech ID/UC Case

19417/2009-183-0

Related Cases

2009-183-0

美国

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