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Enhancement Of Crispr Genome Editing

Technology Benefits: Enhances binding of the Cas9-guide RNA complex to target DNA

Technology Application: Genome editing Site-directed modification of target DNA

Detailed Technology Description: None

Application No.: 9982277

Others

Publication

The homologous recombination machinery modulates the formation of RNA–DNA hybrids and associated chromosome instability

Additional Technologies by these Inventors

Methods and Compositions for Increasing Desiccation Tolerance In a Cell

Tech ID/UC Case

23337/2013-155-0

Related Cases

2013-155-0

*Abstract: When researching genome instability can arise as a result of mistakes occurring during inappropriate hybridization of RNA to its DNA template, UC Berkeley researchers discovered that use of a Rad51 protein could increase the efficiency of Cas9-mediated target DNA modification. The Rad51p helped to join stretches of nucleic acids together to repair breaks in DNA by enhancing the binding of Cas9 polypeptide and guide RNA complex to the target DNA.

*IP Issue Date: May 29, 2018

*Principal Investigator: Name: Douglas Koshland
Department:

Name: Lamia Wahba
Department:

Country/Region: USA

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