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Enhancement Of Crispr Genome Editing

技术优势

Enhances binding of the Cas9-guide RNA complex to target DNA

技术应用

Genome editing Site-directed modification of target DNA

详细技术说明

None

*Abstract

When researching genome instability can arise as a result of mistakes occurring during inappropriate hybridization of RNA to its DNA template, UC Berkeley researchers discovered that use of a Rad51 protein could increase the efficiency of Cas9-mediated target DNA modification.  The Rad51p helped to join stretches of nucleic acids together to repair breaks in DNA by enhancing the binding of Cas9 polypeptide and guide RNA complex to the target DNA.

*IP Issue Date

May 29, 2018

*Principal Investigation

Name: Douglas Koshland

Department:

Name: Lamia Wahba

Department:

申请号码

9982277

其他

Publication

The homologous recombination machinery modulates the formation of RNA–DNA hybrids and associated chromosome instability 

Additional Technologies by these Inventors

• Methods and Compositions for Increasing Desiccation Tolerance In a Cell

Tech ID/UC Case

23337/2013-155-0

Related Cases

2013-155-0

国家/地区

美国