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A PROCESS AND MATERIAL FOR SEALING FAYING SURFACES OF LAP JOINTS FORMED BY FRICTION STIR WELDING

Detailed Technology Description

None

Supplementary Information

Inventor: Satchi Fainaro, Ronit | Folkman, Judah
Priority Number: US6949584B2
IPC Current: A61K0031785 | A61K0039395 | A61K004500 | A61K004748 | A61P000900 | A61P003500 | C07D030322
US Class: 514475 | 549332
Assignee Applicant: Children's Medical Center Corporation,Boston
Title: TNP-470 species, polymer conjugates and use thereof
Usefulness: TNP-470 species, polymer conjugates and use thereof
Summary: The composition is used for treating angiogenic diseases and decreasing neurotoxicity of TNP-470 (claimed). The angiogenic diseases can be diabetic retinopathy, macular degeneration, retrolental fibroplasia, trachoma, neovascular glaucoma, psoriases, angio-fibromas, immune and non-immune inflammation, capillary formation within atherosclerotic plaques, hemangiomas, excessive wound repair, solid tumors, metastases, and Kaposi's sarcoma.
Novelty: Conjugated-polymer containing composition for treating angiogenic diseases e.g. diabetic retinopathy, macular degeneration, or retrolental fibroplasia, comprises O-(chloracetyl-carbamoyl) fumagillol conjugated to water-soluble polymer

Industry

Biomedical

Sub Category

Medical Composition

Others

*Abstract

Non-Confidential Abstract of Invention: Aircraft structures are currently assembled by attaching top-skins to substructures and to other top-skins using rivets. The overlaying skins form lap joints and rivets hold the assembly together. These lap joints form crevices, commonly referred to as faying surface gaps that are prone to corrosion and therefore must be sealed. Current practice is to use a polymer sealant that is applied to the faying surface of the joint just prior to assembly and the sealant undergoes room temperature vulcanization (RTV) to form a barrier to the intrusion of any corroding media. Assembly time is limited by the working life of the polymer RTV sealant. Friction stir welding is a promising new technology for aircraft assembly that has the potential of replacing the riveted joint. However, friction stir welding also employs lap joints in the assembly and these lap joints must be sealed. Current friction stir welding practice also employs polymer sealants that undergo room temperature vulcanization. However, the current polymer sealants degrade the metallurgical integrity of the friction stir welded assembly and limit the assembly time. The sealant and process proposed in this disclosure represent an enabling technology for friction stir welding. The sealant is applied to the joint prior to friction stir welding and the heat generated during welding creates a sealed joint where the sealant has been previously applied. The proposed sealants do not have a limited working time.

*Principal Investigator

Name: David Van Aken

Department:

Name: Yoshihide Kato

Department:

Country/Region

USA