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Collagen-Mimetic Peptide Mediated Delivery of DNA Carriers for Efficient Delivery From Collagen

Detailed Technology Description: Researchers at the University ofDelaware have devised aninnovative and novel method of amplifying the magnitude and duration of transgeneexpression. This method uses the collagen mimetic peptide (CMP) mediateddelivery of non-viral DNA from collagen containing scaffolds. The compositionof the polyplex used is variable, allowing customized release of the contents. CMP – modification has proven to increase thetransgene expression for 10 fold longer duration. The CMP-polyplex-collagencomplex augments the collagen activity in invitro wound models and increase platelet derived growth factor BBexpression for enhanced wound closure rates. These properties make thescaffolds a promising tool in regenerative healing.

Countries: United States

Application No.: Patent Pending

*Abstract

*Inquiry: Denise BierleinLicensing AnalystTelephone: 302-831-4005Email: techtransfer@udel.edu

*IP Issue Date: None

*IP Type: Provisional

Country/Region: USA

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