Collagen-Mimetic Peptide Mediated Delivery of DNA Carriers for Efficient Delivery From Collagen
- 详细技术说明
- Researchers at the University ofDelaware have devised aninnovative and novel method of amplifying the magnitude and duration of transgeneexpression. This method uses the collagen mimetic peptide (CMP) mediateddelivery of non-viral DNA from collagen containing scaffolds. The compositionof the polyplex used is variable, allowing customized release of the contents. CMP – modification has proven to increase thetransgene expression for 10 fold longer duration. The CMP-polyplex-collagencomplex augments the collagen activity in invitro wound models and increase platelet derived growth factor BBexpression for enhanced wound closure rates. These properties make thescaffolds a promising tool in regenerative healing.
- *Abstract
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- *Inquiry
- Denise BierleinLicensing AnalystTelephone: 302-831-4005Email: techtransfer@udel.edu
- *IP Issue Date
- None
- *IP Type
- Provisional
- 国家
- United States
- 申请号码
- Patent Pending
- 国家/地区
- 美国
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